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Mutagenesis 30 , 771784 (2015)

This is because it is a highly reactive free radical and interacts with oxygen and superoxide

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doi: 10.1016/s0065-2423(01)35014-x

Both ubiquitin-proteasome system (UPS) and autophagy-lysosomal pathway have been linked with -synuclein degradation [93], with more recent publications suggesting that UPS is the main -synuclein degradation pathway under normal physiological conditions, while the lysosomal pathway is more responsive to stress or when -synuclein is overly abundant [94, 95]

doi: 10.1097/ALN.0000000000000176