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In vivo , DK-3 treatment reduced tau phosphorylation (Thr181, Thr205, Ser396) and inflammation markers such as IL-6, CoX-2, and IL-1, alleviating neuronal damage (Ji et al., 2021)

Coronal T2-weighted (T2W) MRI scans (2D TurboRAGE) of the whole brain were performed with a vertical-bore 9.4 T Bruker AVANCE 400WB imaging spectrometer with a 250 mTm 1 actively shielded imaging gradient insert (Bruker BioSpin, Billerica, MA) controlled by Paravision software

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Instead, it serves as a reservoir for reduced L-glutathione

Annu Rev Pharmacol Toxicol 43:23360 Dinkova-Kostova AT, Holtzclaw WD, Cole RN, Itoh K, Wakabayashi N, Katoh Y, Yamamoto M, Talalay P (2002) Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants