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Hepatology 2019;70:496510

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As a result, upregulation of NRF2 target genes resulted in growth advantages and cisplatin resistance of lung cancer cells.17 Although the nature of NRF2 mutations, which involve direct DNA changes, results in loss of affinity for binding to the KELCH region, the KEAP1 mutations create steric hindrance and gross structural changes in the formation of the NRF2:KEAP1 complex

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P814, P815 Barmanray R

While our study design did not allow for a direct selenium measure to be accurately determined, we sought to utilize a targeted acquisition to determine if other selenium-containing proteins were also reduced in abundance as observed for GPx3