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It is especially important to improve chemotherapy in pediatric patients since children are undergoing an essential stage of bone development requiring growth factors, including IGF-1 and VEGF, for bone elongation

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Common signs of fluid overload include: Edema in the extremities Shortness of breath Elevated blood pressure Compromised kidney function Repeated needle insertions also increase the risk of localized complications at the IV site, such as infection, bruising, and vein irritation

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