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Long-chain polyunsaturated fatty acids are highly enriched in the nervous system

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This trend was confirmed in fibroblasts (Figure 1D), with high GSH levels in II-1 (50 0.88 nmol/mg prot.) and low concentrations in I-2 (25 0.33 nmol/mg prot.), II-2 (36 0.37 nmol/mg prot.), and I-1 (27 0.35 nmol/mg prot.)

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Here are some key concerns: Increased Oxidative Stress : A decrease in glutathione levels can lead to increased oxidative stress, which is associated with various chronic diseases, including cardiovascular disease, diabetes, and neurodegenerative disorders