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High In Vivo Rates of Methionine Biosynthesis in Transformed Human and Malignant Rat Cells Auxotrophic for Methionine

10.1093/pcp/pcv196 109 PengH

Vasilj, A

Another study reported BD patients (75 euthymic, 14 manic/hypomanic, 45 depressive) had higher levels of all cytokines, including slL-2R, C-reactive protein (CRP) and sTNFR1 than the healthy controls [73], with depressed BD patients having reduced sTNFRl and slL-2R compared to those in mania and euthymia [73]

Notably, this analysis also highlighted growth/immune signaling modules linked to AKT biology, including CD28-dependent PI3KAkt signaling, providing further support for AKT1 as a convergent node emerging from coordinated epigenetic and transcriptional alterations

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