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Interestingly, it can take years for B12 stores to deplete to a point where a deficiency becomes apparent: Vitamin B12 deficiency affects multiple systems, and sequelae vary in severity from mild fatigue to severe neurologic impairment

20512058, Sep

AJOVY HAS A LONG HALF-LIFE 1 This information should not be construed to imply any difference in safety, efficacy, or other clinical outcome

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The Journal of biological chemistry

Oral supplements pass through the digestive tract to be absorbed by the bloodstream, and much of the nutrient is lost in this process
