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Goetz CG

Severe loss of quality of life, due to symptoms such as debilitating fatigue, insomnia (B12 is required for synthesis of melatonin), mental illness, and neurological symptoms

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This property allows a small amount of PQQ, in the picomolar range, to convert a micromolar quantity of product, as evidenced in references (Stites et al., 2000

Fatigue, weakness, especially lightning bolt sensations type of pain, joint pain, muscle pain, cognitive impairment, anxiety unrelated to stressors (eg a physical anxiety without a life trigger), depersonalization / derealization, depression, skin sensitivity, emotional lability, thermal lability, vertigo, dizziness, nausea, vomiting - and more