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OXPHOS defects involve energetic cost, hypermetabolism, and increased aging velocity in most, if not all, organs (Diaz-Vegas et al., 2020

The balance between osteoclasts and osteoblasts involved in subchondral bone remodeling was affected under these conditions, and it was observed that iron overload compromises synovial homeostasis coordinated by synovial lining hyperplasia

doi: 10.1016/j.jtemb.2020.126500 8 HouKLiuLFangZ-HZongW-XSunDGuoZet al

Additionally, Caliari et al

thus, confirming the role of Mat1a -induced BAT thermogenesis in the improved phenotype

Even more specifically, rats studied predominantly by one research group in Zagreb, Croatia
