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OXPHOS defects involve energetic cost, hypermetabolism, and increased aging velocity in most, if not all, organs (Diaz-Vegas et al., 2020

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The balance between osteoclasts and osteoblasts involved in subchondral bone remodeling was affected under these conditions, and it was observed that iron overload compromises synovial homeostasis coordinated by synovial lining hyperplasia

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doi: 10.1016/j.jtemb.2020.126500 8 HouKLiuLFangZ-HZongW-XSunDGuoZet al

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thus, confirming the role of Mat1a -induced BAT thermogenesis in the improved phenotype

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Even more specifically, rats studied predominantly by one research group in Zagreb, Croatia

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