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Activation of plaque macrophages by other immune cells through CD40TRAF6 signaling triggers NF-B activation, amplifies pro-inflammatory cytokine secretion, promotes macrophage polarization towards the M1 phenotype, and enhances immune cell recruitment, collectively contributing to the progression of atherosclerosis

Cell 128 , 635638 (2007)

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In addition, changes in histone marks, such as increased acetylation or decreased methylation, lead to chromatin relaxation, thereby increasing DNA accessibility and susceptibility to damage from ROS and IR (112, 113)

GLP-1 Injections GLP-1 (Glucagon-Like Peptide-1) injections, such as tirzepatide and semaglutide, are increasingly used for weight management

Kaplowitz et al