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Description

Nature, 395 (6704), 763770

Studies have demonstrated that functional impairment of certain extraintestinal organs can induce oxidative stress, provoke an inflammatory response, and disrupt metabolic homeostasis in the intestine, thereby impacting intestinal barrier function

This is why supplementation is often recommended

& Gong, G

MSM appears to be safe and studies report only minimal side effects

Also, the significant upregulation of plasma proteins (IGFBP4, fetuin-B, tetranectin, and vitamin K-dependent protein S) was tentatively proposed to be associated with osteoclast activity