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Folate deficiency leads to the accumulation of homocysteine which is associated with an increased risk of cerebrovascular diseases, depression, and dementia, with a focus on vascular dementia and Alzheimers disease (, , )

The extended survival of tolerant bacteria further predisposes them to evolve antibiotic resistance over time, underscoring the critical need to address antibiotic tolerance

Long-term hypercholesterolemia has also been shown to cause chronic cavernosal tissue injury that may be only partially reversible after lipid normalization (40)