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Nrf2 also establishes the crosstalk with other radioresistancerelated signaling pathways such as HIF1136 and NFkB137 against radiotherapy

Moreover, Recknagel, Glende Jr [51] and Szymonik-Lesiuk, Czechowska [52] revealed that CCl 4 metabolism generates free radicals, which cause liver tissue lipid peroxidation, higher MDA levels, and decreased antioxidant enzyme activity, including GPx, respectively

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