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Because this strategy leverages native genome-recognition machinery, it preserves the native capsid architecture more effectively than artificial charge-based loading methods

Belkind-Gerson J, Hotta R, Nagy N, Thomas AR, Graham H, Cheng L, Solorzano J, Nguyen D, Kamionek M, Dietrich J, Cherayil BJ, Goldstein AM

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In those materials, the Agency highlighted recurring issues: limited or inadequate safety data, concerns about characterization and impurities, lack of evidence of historical use in compounding, and potential immunogenicity risks

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doi: 10.1111/j.1525-1497.2006.00525.x
