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RSL3 is an inhibitor of GPx4, and studies have found that the PERK inhibitor GSK414 not only suppresses the expression of the ER stress signaling pathway eIF2/ATF4/CHOP induced by RSL3 but also reduces cellular ferroptosis, improving experimental colitis in mice

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Oxidative stress and neutrophil activationthe two keystones of ischemia/reperfusion injury

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