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Interestingly, SAAR decreased liver lysine lactoylation, a SAA-supported post-translational modification known to inhibit PHGDH enzymatic activity

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Research should focus on personalized approaches to antioxidant therapy, taking into account individual variations in ROS levels, antioxidant capacity, and underlying health conditions that may influence the effectiveness of treatment

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Furthermore, decreased NAD+ levels, potentially a consequence of reduced kynurenine, may contribute to fatigue by impairing energy production, and disrupting the coordination of circadian rhythms necessary for effective sleep (reviewed in Dehhaghi et al., 2020)

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