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The Peptide Mechanisms That Target Venous Wall Integrity Venous insufficiency and varicose vein formation fundamentally involve three overlapping pathological processes: endothelial dysfunction (the inner lining of veins loses its barrier function and regulatory capacity), extracellular matrix degradation (collagen and elastin fibers that give vein walls structural strength break down faster than they're replaced), and chronic low-grade inflammation that compounds both problems

Its dramatic age-related decline is significant: plasma concentrations average 200 ng/mL at age 20 but typically plummet to 80 ng/mL by age 60a 60% reduction correlating with visible aging and reduced healing capacity

the composition of the present invention is made by admixing these ingredients according to a conventional method
