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[DOI] [PubMed] [Google Scholar] 32.Wang X, Chu S, Qian T, Chen J, Zhang J

In mammals, heterodimers of Brain and muscle ARNT-like protein-1 (BMAL1) and Circadian locomotor output cycles kaput (CLOCK) activate the transcription of the clock genes Period ( Per1-3 ) and Cryptochrome ( Cry1/2 ) throughout the day while their protein products, PER1-3 and CRY1/2, inhibit CLOCK:BMAL1 and consequently their own transcription during the night 1

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At a Glance Children with Glutaric Acidemia Type 1 face an increased risk of long-term kidney strain because their kidneys constantly filter excess toxic acids

doi:10.1016/S0140-6736(14)60763-7

Distinctive roles of furin and TMPRSS2 in SARS-CoV-2 infectivity