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Endosomal Toll-like receptors (TLR3 and TLR7) bind to ssRNA in the endosome, while components of the inflammasome such as MDA5, RIG-I, NOD2 and PKR bind to ssRNA and dsRNA in the cytosol, resulting in cellular activation, and production of type I interferon and multiple inflammatory mediators 7 (Fig

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Not only that, but the combination of drugs also leads to impressive reductions in body weight that were significantly higher than the weight loss experienced with metformin alone