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Studies indicate that NNMT inhibition by compounds such as 5-Amino-1MQ can result in reduced fat mass and improved insulin resistance

It modulates neurotransmitter systems including dopamine and serotonin

The most common experience is heavy bloating, especially after eating, and an alternation of diarrhoea or constipation may occur, giving symptoms very similar to that of Irritable Bowel Syndrome

Other nutrient deficiencies impede cofactors

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Although primarily known as a pro-inflammatory cytokine that binds to cell membrane receptors to potentiate intracellular signaling 45 , eNAMPT can also be taken up by cells such as neurons and increase NAD + synthesis 46