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Description

ADNF-9 (Ser-Ala-Leu-Leu-Arg-Ser-Ile-Pro-Ala, SALLRSIPA)

Insulin-like growth factor-I receptor/human epidermal growth factor receptor 2 heterodimerization contributes to trastuzumab resistance of breast cancer cells

After the papules resolve, post-inflammatory hyperpigmentation emerges (234, 235)

Improves Physical Health: The activation of the vagus nerve has a positive impact on various bodily functions, including heart rate, digestion, and immune response, contributing to overall physical health

When melanocytes are hyperactivated by specific triggers UV radiation, post-inflammatory signals from acne or injury, hormonal changes (especially estrogen and progesterone in melasma), or genetic predisposition they produce excess melanin that accumulates in patches, creating dark spots, uneven tone and visible discolouration