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doi:10.1007/s12016-011-8291-x [39] Karlsson F, Tremaroli V, Nielsen J, Bckhed F

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Thus, the fed state is an insulinsufficient state in which insulin affects the internal machinery of cells in the liver, adipose tissue, and muscles to promote energy production and storage [124]

This explains why PDE5 inhibitors are ineffective in individuals whose primary deficit is diminished desire rather than impaired hemodynamic response [4, 17]

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