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They may either stimulate or inhibit immunological responses
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Functional MRI in migraine

BMC Health Serv Res 20:1144 Lamers F, Milaneschi Y, Penninx BWJH (2018) Depression subtypes and inflammation: atypical rather than melancholic depression is linked with immunometabolic dysregulations

Consequently, the compromised BBB allows the virus to breach the brain's protected environment while also permitting the entry of pro-inflammatory cytokines

This might need to be supplemented with medication
