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Saitoh W, Yamauchi S, Watanabe K, et al

In research environments, this combination is used to examine peptide synergy, receptor binding behavior, and signaling pathway dynamics across multiple peptide classes

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MDM2 was proven to ubiquitinate the IGF-1R and degraded it in a proteasome-dependent manner (Girnita et al, 2003), eventually leading to cell death

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