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It remains to be determined whether boosting complimentary routes with exogenous substrates, such as citrate, or genetic/pharmacological interventions to increase ME1 or IDH1 levels and/or activity, is sufficient to counteract the excessive oxidative stress and hemolysis seen in G6PD def erythrocytes

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References Mnty M, Kuh D, Cooper R

Mediterranean diet amplifies glucose effects

Targeting these gametocytes is crucial for interrupting the parasites life cycle

4.3 Patient selection and clinical considerations Despite the therapeutic potential of antioxidants, their use should not be considered universal nor as a replacement for conventional therapy [58]