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Hippocampal astrocytes modulate anxiety-like behavior

instead, the term is used by patients and some providers to describe several symptoms, including fatigue and muscular pain, attributed to prior infection with Lyme disease

Participants with renal impairment were excluded if they had previously undergone renal transplantation or had unstable renal function or acute exacerbation of renal disease within 14 days of baseline, as indicated by recent history or worsening of clinical or laboratory signs

We hypothesized ALDH1A1 and sirtuins to be potential candidates for this, due to their notable expression levels and participation in astrocytic GABA-associated disease pathology

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Nasal spray considerations: Typically lower bioavailability than injection, requiring somewhat higher doses Faster onset in some users due to direct CNS access More convenient and less intimidating for needle-averse individuals Requires properly calibrated spray bottles for accurate dosing Converting from injectable to nasal dosing is not straightforward