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Ca can originate from intracellular organelles or enter from the extracellular environment through specific ion channels, including Ca release-activated Ca channels, transient receptor potential (TRP) channels and L-type voltage-gated Ca channels

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Data so far obtained indicates that there are at least two direct bilirubin receptor targets, one at physiological levels (PPAR) and another at higher pathological concentrations (MRGPR)

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