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Major source of methyl groups Choline may be oxidized in the liver and kidney to form a metabolite called betaine via a two-step enzymatic reaction

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It participates in the modulation of the activity and localization of numerous enzymes and receptors [147, 160, 161], takes part in the regulation of many physiological processes in the brain [147, 162], including synaptic plasticity [163, 164], axonal elongation, and neuronal survival [147, 165]

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