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(2019) 176:64962.e20

Although Cd does not undergo redox reactions like copper, it can induce DNA damage through the generation of ROS in the presence of hydrogen peroxide

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Barnes RP, Fouquerel E, Opresko PL

Osterlund E, Maddalena G, Pellatt AJ, Eluri M, Parseghian C, Aziz K, Alfaro K, Kell RJ, Manyam GC, Konishi T, Overman MJ, Morelli MP, Willis J, YC Shen JP, Singh Raghav KP, Newhook TE, Dasari A, Maitra A, Van K Morris II, Kopetz S

After the cells were treated with 0.5, 1, 2, 3, 4 mM of ALA and/or 30 cisplatin for 30 h, 0.5 mg/mL of MTT solution was added to cell culture media, followed by incubation for 2 h at 33 C with 10% CO 2