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Large scale production of the active human ASCT2 (SLC1A5) transporter in Pichia pastoris functional and kinetic asymmetry revealed in proteoliposomes

This mechanistic switch leads to oxidative DNA damage and enhanced carcinogenesis, accounting for the population-specific toxicity (246)

Calcium overload within the sarcoplasmic reticulum (SR) can trigger spontaneous diastolic Ca 2+ releases through ryanodine receptors (RyR2), generating delayed afterdepolarizations (DADs) and potentially causing arrhythmias [53]

PerkinElmer, Waltham, MA, U.S.A.) and normalized to that of four control wells containing only medium to assess cell viability

[DOI] [PubMed] [Google Scholar] 74."Off" painful dystonia in Parkinson's disease treated with botulinum toxin

[DOI] [PMC free article] [PubMed] [Google Scholar] 59