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26 In this model the changes normalized within a few days and no morphological alterations were found up to 4 weeks

Studies have shown that IGF-l and IGF1R mRNA expression in cultured young intervertebral disc cells is higher than that in mature cells, and the decrease of IGF-l dependent protein polysaccharide synthesis in rat NPCs is due to the downregulation of IGF-IR in late senescence (Osada et al., 1996

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However, new techniques involving transcutaneous electrical stimulation of the vagus nerve are currently being explored as safer, less invasive, and less expensive options

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