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It was first discovered from extracts that include yeast, animals, and eggs.

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MAPK pathways Mammalian cells express three major classes of MAPKs, the extracellular signal-regulated kinases (ERK), c-Jun N-terminal kinase/stress-activated protein kinases (JNK/SAPK) and p38 kinases, the activation of which results in the stimulation of transcription factors and the regulation of the expression of cell cycle proteins [ 32 , 33 ]

It also faces certain development challenges, showing an overall trend of coexisting potential and opportunities, which can be summarized in the following aspects

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The Pyo study was in vitro