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This dynamic range is higher than recently developed biosensors such as the FiLa lactate sensor (1,500%-2,700%) (Li et al., 2023), iATPSnFR2 ATP sensor (1200%)(Marvin et al., 2024), or the redox biosensors roGFP2 (600-1200%)(Pedre, 2024), HyPer7 (500%)(Pak et al., 2020), SoNar (1500%)(Zhao et al., 2015) or iNap (900%) (Tao et al., 2017)

(2) the activity of the antioxidant enzymes catalase (CAT) and superoxide dismutase (SOD)

Its low toxicity in normal cells, coupled with its robust anti-tumor effects in vitro and PDO models, underscores its potential for clinical translation

Copper and bacteria

H., Nery, P

2022;26(2 Suppl):7281