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doi:10.1586/14789450.2014.965159
The study also revealed that MeCbl worked by inhibiting certain inflammatory pathways in the spinal cord, which are activated by vincristine, thereby balancing pro-inflammatory and anti-inflammatory signals

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Regarding small molecule inhibitors targeting NNMT, challenges include the identification of efficient and selective inhibitors with robust in vivo activity ( 6 Conclusion NNMT is considered to play a significant role in MetS-related diseases