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doi: 10.1016/bs.irn.2020.02.007

YJ: Conceptualization, Funding acquisition, Supervision, Writing review & editing

In a continuous breeding study, pregnant mice received 0.25, 0.5, or 1.0% acetaminophen via the diet (357, 715, or 1,430 mg/kg/day)

Therefore, aloe-emodins ability to reverse drug resistance, inhibit metastasis, and enhance the effectiveness of other chemotherapeutic agents, such as gemcitabine and temozolomide, underscores its potential as a valuable adjuvant in cancer therapy

This appears to also result in reduction of pro-inflammatory cytokines such as IL-1 and IL-18 in macrophages and mice 48

The DNA content histogram of untreated control cells (Fig