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A Highly Productive System for Cell-Free Protein Synthesis Using a Lysate of the Hyperthermophilic Archaeon, Thermococcus Kodakaraensis

Moreover, over 40% of people who start taking GLP-1s quit the medicines within 2 years due to high costs and gastrointestinal side effects such as nausea, diarrhea, vomiting, and constipation, according to a study published in JAMA Network Open last year

[PubMed: 21734188] 791

This indicates that, as in macrophages, choline metabolism also modulates microglial inflammatory responses, and manipulating choline metabolism may promote a neuroprotective phenotype