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In a randomized, double-blind, placebo-controlled trial in 2,919 participants (65 years) with elevated blood concentrations of homocysteine, supplementation with vitamin B 12 (500 g/day) and folic acid (400 g/day) for two years did not decrease the risk of osteoporotic fracture despite reductions in homocysteine (120, 121)

If FDA is unable to post the background material on its website prior to the meeting, the background material will be made publicly available at the location of the advisory committee meeting and on FDAs website at the time of the advisory committee meeting

The role of vitamin B12 and genetic risk factors in the etiology of neural tube defects: A systematic review

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Cellular senescence: "Zombie cells" that secrete inflammatory factors, promoting further aging