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All flavonoids share a core structure consisting of two aromatic benzene rings (A and B) connected by a threecarbon bridge, forming a heterocyclic pyran ring (C), commonly referred to as the C6C3C6 skeleton [33]

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Conversely, administration of 17 estradiol has been shown to alleviate neuropathic pain in male rats following nerve injury [488]

doi: 10.3168/jds.2012-5979 18 SilvaTHGuimaraesIMentaPRFernandesLPaivaDRibeiroTLet al