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When cortisol-related symptoms persist despite lifestyle modificationincluding progressive central weight gain, easy bruising, proximal muscle weakness, wide purple striae, resistant hypertension, unexplained osteoporosis, or hypokalemiaformal endocrine evaluation is warranted to exclude pathological hypercortisolism requiring specialized intervention

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Yang et al., 2010

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Extracorporeal shock wave therapy ameliorates cyclophosphamide-induced rat acute interstitial cystitis though inhibiting inflammation and oxidative stress in vitro and in vivo experiment studies