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2012 Sep [cited

(2009) provided evidence that vitamin C/E supplementation in humans during shortterm (4 weeks) exercise training can impair improvements in insulin sensitivity, as assessed by glucose infusion rates during a hyperinsulinaemic, euglycaemic clamp

Based on the close similarity of the NO-assays in other tissues (e.g

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Several mechanisms have been suggested to account for the liver damage caused by APAP, including disturbed hepatic GSH reserves, inhibition of cytochrome P450 enzyme activity, elevation of intracellular calcium levels, increased LPO and ROS formation (236)

For neuroprotective mitochondria-targeted drugs with several systemic side effects, such as pitavastatin and pentoxifylline, intranasal drug administration could be a promising option to target the CNS using a lower dose that would minimize systemic exposure, thus decreasing the unwanted adverse systemic effects