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Under high copper concentrations, free intracellular copper ions accumulate and inhibit enzyme function by oxidizing cysteines in iron-sulphur cluster proteins or react chemically with hydrogen peroxide to generate highly reactive hydroxyl radicals, thereby inducing cellular damage (12)

Ndrepepa G, Colleran R, Kastrati A

J Surg Res 163(2):244-9, 2010

ApoE3 is the most common variant, occurring in approximately 7080% of people, and is considered neutral with no strong influence on atherosclerosis or dementia risk

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