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G6PD-deficient individuals are also at a high risk of severe hemolysis when given anti-malarial drugs, such as quinine, primaquine or chloroquine, through irreversible oxidative activity of their metabolites on erythrocytes 8,9

2020 doi: 10.1016/j.ejps.2019.105158

Rx Only 5 mL Product does not contain plasma/albumin Single-dose only Takeda 6521323 IU: LOT: EXP: ADVATE [Antihemophilic Factor (Recombinant)] For Intravenous Administration Only Rx Only ADVATE and diluent preassembled in BAXJECT III system Directions for use: see package insert Product does not contain plasma/albumin 6521316 Takeda IU: LOT: EXP: ADVATE [Antihemophilic Factor (Recombinant)] NDC 0944-3047-10 Single-dose only For Intravenous Administration Only Rx Only Lyophilized powder for reconstitution ADVATE and diluent preassembled in BAXJECT III system Product does not contain plasma/albumin ACTUAL POTENCY 5 mL Takeda ADVATE [Antihemophilic Factor (Recombinant)] NDC 0944-3047-11 For Intravenous Administration Only ADVATE and diluent preassembled in BAXJECT III system Do not open until time of use Do not use if packaging is opened or damaged Discard unused portion

Am J Physiol Gastrointest Liver Physiol 313:G157-g165

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When selecting the protease cleavage site, be sure that the protein of interest does not contain an internal recognition sequence for this protease