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Cancer Cell (2016) 30(4):56377

Interestingly, the administration of SP, L-car, and their combination was able to reverse the changes in hormonal levels as presented in the DOX + SP, DOX + L-car, and DOX+(SP + L-car) groups, especially the DOX+(SP + L-car), unlike the DOX group, reflecting their protective role against ovarian toxicity induced by DOX

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Additionally, hypothalamic ACE2 receptors are implicated in the suppression of corticotropin-releasing hormone synthesis, which is a crucial component of the physiological stress response [96-101]

10.1016/j.bbrc.2005.05.174 Biochem

Sparano JA