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Dietary zinc restriction in rats alters antioxidant status and increases plasma F2 isoprostanes

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Results Effect of MDR ABC transporters on the toxicity of anticancer chelator ligands We studied the toxicity of various chelators in the presence of 2 M Cu(II) or 10 M Fe(II) ions against A431 cells and their multidrug-resistant derivatives overexpressing ABCB1, ABCG2, or ABCC1

Proc Natl Acad Sci 116:1251612523

The PCR products were analyzed by scanning densitometry (Image J, NIH) and values were normalized to quantity of -actin and presented as % mRNA relative to control

However, certain non-enzymatic antioxidants such as glutathione, ubiquinone, albumin, metallothioneins, and uric acid are predominantly produced endogenously (155, 168)