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Impairment of autophagic degradation and mitochondrial dysfunction are also significant factors, as evidenced by accumulation of autophagosomes and suppression of mitochondrial oxygen consumption rates in DOX-treated hearts [14]
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Nrf2 is also involved in the regulation of genes that control the cell cycle, apoptosis, and DNA repair

For instance, cetaceans that have adapted to different diving depths have demonstrated different rates of evolution for HBA , HBB , and other associated genes (Tian et al., 2016)

Cimetidine a promising radio-protective agent through modulating Bax/Bcl2 ratio: an in vivo study in male rats
