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Decreased NO and increased oxidative stress (OS) impairs endothelial [34,35] and macrophage function [36] and increases inflammatory cytokines, such as tumor necrosis factor (TNF) and monocyte chemoattractant protein-1 (MCP-1) in endothelial cells and monocytes [34,35]

Irisin and neuroinflammation: Challenges and opportunities

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doi: 10.1016/j.cmet.2016.03.016

Currently, abstinence, corticosteroids, and nutritional therapy remain conventional therapeutic interventions for ALD