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Description
Peak serum concentration (Cmax) occurs at approximately 1520 minutes, followed by rapid first-order elimination

This design significantly enhanced the targeting efficiency and therapeutic potency of the prodrugs while minimizing off-target toxicity

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Moreover, the beneficial effects of melatonin on mouse hearts, which depend on the regulation of ALDH2 activity, could not be assessed due to mutations or deficiencies in ALDH2

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