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This is because some sporadic tumours show MSI without an underlying germline mutation (i.e
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In fact, since D+Q targets a range of biological pathways in diverse tissues, it is generally difficult to attribute cell type-specific biological effects to the senolysis itself (45, 103, 112)
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Speichinger notes that sometimes there is a second step to the progesterone challenge, where estrogen is given first and followed by progesterone, to cause the withdrawal period
doi: 10.1039/c1cp21366k
