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10.1016/j.optmat.2018.04.017 157 PushpanathanS.GunasekaranA.NatarajanS

Kasperkovitz, P

Collectively, the interplay between GSH, GPX4, and cellular resilience highlights the potential of GSH-targeted strategies to improve the efficacy of standard treatments and possibly alleviate drug resistance in cancer therapy

doi: 10.1016/0014-5793(79)80069-1

Mol Biochem Parasitol

Mechanistically, they demonstrated that STUB1 promoted polyubiquitination of GPX4 on lysine 191, leading to its degradation by the ubiquitin proteasome pathway
