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doi: 10.1073/pnas.1817473116

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Apart from leptin, the hypothalamic-pituitary-gonads (HPG) axis and spermatogenesis are also affected by other pro-inflammatory cytokines produced in excess by the WAT, such as tumour necrosis factor (TNFa, tumor necrosis factor-a), interleukin-6, chemerin, resistin, or ghrelin [24]

Since many pathologic and toxic conditions can lead to activation of CMK and phosphorylation of GCLC, inhibition of GCL may further contribute to toxicity
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doi: 10.1111/andr.13257 13 AminKMEl-BadryOMAbdel RahmanDEAbdellattifMHAbourehabMASEl-MaghrabeyMHet al